PEG MGF

Understanding PEG MGF

PEG MGF is a man-made version of a natural growth factor called Mechano-Growth Factor (MGF). MGF comes from a gene called Insulin-like Growth Factor-1 (IGF-1). Scientists have added a special chemical called polyethylene glycol (PEG) to this growth factor, which makes it last much longer in the body. The longer it lasts, the longer it can keep working. Scientists use PEG MGF to study how it helps cells repair and grow. It's only for research purposes and cannot be used in people or animals.

What PEG MGF Does

PEG MGF is a laboratory version of the natural growth factor Mechano-Growth Factor, which comes from the Insulin-like Growth Factor-1 gene. Scientists added a polymer chain called PEG to make it more stable and help it stay in the body longer compared to the regular version of MGF.

Having this extra time means PEG MGF can help cells repair and grow for much longer in research settings. This makes it really useful for scientists studying muscle repair, tissue healing, how cells fix themselves, and how growth signals work. The longer-lasting effect helps scientists see exactly what PEG MGF does to make muscles bigger, activate special repair cells, and help cells handle physical stress.

PEG MGF is only for laboratory research. It has not been approved for use in humans or animals and should only be used by trained scientists in research labs.

Chemical Structure of PEG MGF

Research with PEG MGF

Muscle Repair and Healing

Muscle injuries happen often in sports and exercise. These injuries can be small tears or big tears that might even separate the muscle completely. Many injuries need surgery, and healing can take a long time with unpredictable results even with medical care. Animal studies show that when scientists inject MGF directly into a damaged muscle, it can help protect the cells by reducing inflammation and preventing oxidative damage (damage from harmful molecules in the body).

Research by Sun and his team found that MGF helps reduce inflammation in muscle and brings immune cells like macrophages and white blood cells to the injury site to help with healing. This builds on what scientists already know—that exercise-induced muscle damage causes the release of related growth factors called IGF-1Ea and IGF-1Eb.

A group of international endocrinology researchers discovered that MGF activates the same growth factor receptor as IGF-1, the main growth-promoting hormone. Activating this receptor has been connected to anti-aging effects, more muscle mass, and better energy management in the body. This means PEG-MGF might work similarly to IGF-1, potentially helping muscles repair and stay healthy.

Heart Muscle Repair

Research from the University of Illinois Bioengineering Department shows that MGF can stop the programmed death of heart muscle cells that happens during a heart attack when the heart doesn't get enough oxygen. MGF also seems to bring special heart repair cells to the damaged area, which could help the heart heal after a heart attack. When rats received MGF within eight hours after not having enough oxygen, they had less cell death and more repair cells compared to rats that didn't get treated. The lead researcher, Dr. Doroudian, thinks that using tiny particles to deliver MGF to damaged heart tissue could be an effective way to give the treatment long-term.

Other studies show that when MGF is delivered to a specific heart area after damage, the heart can work better and the heart muscle doesn't get abnormally enlarged (which happens after a heart attack). Rats given PEG-MGF had better heart function, better blood flow, and less damage to the heart structure compared to untreated rats. Another researcher named Carpenter found that MGF can reduce heart cell death by up to 35% after a heart attack.

Protecting Cartilage in Joints

Research shows that MGF helps the special cells in cartilage (called chondrocytes) work better. These cells are responsible for making and maintaining cartilage. Animal studies show that MGF helps cartilage cells move from bone into cartilage areas where they do their repair work. This makes PEG-MGF really good for treating damaged joints because it lasts much longer than regular MGF. One dose of PEG-MGF could potentially work for weeks or even months, while regular MGF only works for minutes or hours.

Teeth and Gum Health

Lab studies using human gum cells found that PEG-MGF helps cells become bone-forming cells and increases chemicals (MMP-1 and MMP-2) that help break down old tissue so new tissue can grow. These effects could help regrow the ligaments that attach teeth to bone, which might help people keep their natural teeth instead of needing implants or extractions. Scientists also think that one day PEG-MGF might be able to help fix teeth that have been knocked out and re-implanted back into the mouth.

Who Wrote This

Dr. Geoffrey Goldspink, Ph.D., a famous muscle and growth factor scientist, compiled and organized this review. Dr. Goldspink is best known for discovering Mechano-Growth Factor, which comes from the Insulin-like Growth Factor-1 gene. His research showed how mechanical stress (like exercise) can turn genes on and off and help tissues repair and grow, especially in muscles, bones, and cartilage. Dr. Goldspink has spent his career studying growth factors and how they help repair tissues, especially MGF and its modified forms like PEG-MGF.

The Main Scientist

Dr. Geoffrey Goldspink, Ph.D., is a retired professor who studied muscle and how genes work at University College London. He has published many scientific papers explaining how Mechano-Growth Factor works in muscle repair, how it helps cells adapt, and how it sends signals to cells. He worked with other scientists named Y. Li, P. Williams, and V. Kandalla to figure out how MGF makes tissues grow, turns on growth receptors, and helps tissues repair.

Dr. Goldspink is known worldwide as the top expert on MGF and how it works. This mention is just to recognize his scientific work, not to recommend this product. Montreal Peptides Canada has no relationship with Dr. Goldspink or any of the other scientists mentioned.

References

Yang S, Cui H, Chai X, et al. Mechano growth factor, a splice variant of IGF-1, promotes neurogenesis in the aging mouse brain. Mol Brain. 2017;10:23. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5500367/

Vassilopoulos A, Constantinou C, Clayton R, et al. MGF: a local growth factor or a local tissue repair factor? Physiology (Bethesda). 2010;25:139-149. https://physoc.onlinelibrary.wiley.com/doi/full/10.1113/expphysiol.2009.048511

Goldspink G, Li Y, Williams P, et al. Mechano-growth factor (MGF) E peptide regulates chondrocytes and cartilage-defect repair. J Orthop Res. 2023 (review). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10281885/

Kandalla PK, Goldspink G, Mouly V, Butler-Browne G. Mechano-Growth Factor E peptide derived from an isoform of IGF-1 activates human muscle progenitor cells. Mech Ageing Dev. 2011;132(4):154-162. https://pubmed.ncbi.nlm.nih.gov/21354439/

Core Peptides. PEG-MGF peptide: research in tissue repair and cell regeneration. 2023. https://www.corepeptides.com/peg-mgf-peptide-research-and-cell-regeneration/

HHM Global. Pegylated Mechano-Growth Factor peptide overview. 2024. https://hhmglobal.com/health-wellness/pegylated-mechano-growth-factor-peptide-overview

Swolverine Blog. PEG-MGF for beginners: muscle repair, dosing, and stacking guide. 2024. https://swolverine.com/blogs/blog/peg-mgf-for-beginners-muscle-repair-and-stacking-guide

TRT MD. PEG-MGF (Pegylated Mechano Growth Factor) - muscle repair and growth. 2024. https://trtmd.com/peg-mgf-muscle-repair-growth/

Clinical research database. Study of MGF analogues in muscle repair. ClinicalTrials.gov. https://clinicaltrials.gov/ct2/results?cond=Mechano-Growth-Factor